Additional Information

Description

Nitrostat 0.4 mg Tablet is a medication used for the relief and prevention of angina pectoris (chest pain) caused by coronary artery disease. The tablet contains 0.4 mg of nitroglycerin as the active ingredient. It is typically used for the acute management of angina episodes and as a prophylactic treatment for patients who experience frequent angina attacks..

The mechanism of action of Nitrostat involves the relaxation of smooth muscle and the dilation of blood vessels. Nitroglycerin is converted to nitric oxide in the body, which then activates the enzyme guanylate cyclase. This leads to increased levels of cyclic GMP, resulting in the relaxation of vascular smooth muscle, particularly in the veins. The dilation of blood vessels reduces the heart's workload.

Nitrostat is usually administered sublingually, allowing for rapid absorption into the bloodstream. It is commonly used in patients who experience episodic chest pain or during an acute angina attack. The tablet should be placed under the tongue and allowed to dissolve without chewing or swallowing for optimal effect.